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Its specific target is the regeneration of brain cells in the cerebral cortex, the outer layer of the brain responsible for higher cognitive functions including reasoning, language, planning, and sensory processing

PubMed Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA (2011)

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However, a combination of K-sparing diuretics such as amiloride and thiazide results in an equivalent CCB treatment and causes fewer side effects than thiazide alone (glucose intolerance and hypokalemia)