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In some embodiments, the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof, is essentially dissolved in the otic pharmaceutical formulation or composition

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Depending on the formulation, they may provide additional antioxidant or nutritional properties

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Additionally, it induces cytotoxicity and diminishes the clonogenic potential of these cells by inhibiting Axl activation and downregulating TAM receptor tyrosine kinases (RTKs), which are vital for cancer cell survival and growth [236]