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Mandate inclusion of LMIC patients in international clinical trials to ensure therapeutic relevance and accessibility across populations

These studies suggest that inhibition of the L-carnitine shuttle by pharmacological inhibition of CPT I, as in the case of etomoxir, results in liver steatosis

Pregnant and breastfeeding individuals should avoid supplementation without explicit provider approval due to limited safety data in these populations

[DOI] [PubMed] [Google Scholar] 20.May M., Vernoux T., Leaver C., Montagu M.V., Inz D

Most gastroenterologists recommend trying dietary modification and over-the-counter remedies first, reserving prescription interventions for cases where symptoms persist beyond 8 weeks