An oxidant/antioxidant imbalance characterized by oxidative stress and low GSH levels is involved in the pathogenesis of idiopathic pulmonary fibrosis, since data show marked GSH deficiency in the lower respiratory tract of those patients (127)
This process could shift the fibrotic response from pathological persistent collagen deposition to physiological collagen contraction
4,5,6,7 The important part of NAD+ is that its a long game
Cartilage destruction in RA is closely linked to the oxidative stress environment, and the hypoxic environment increases monocyte differentiation toward osteoclasts and elevates osteoclast activity ( Figure 3 )
Identification of Polycomb Group Protein EZH2-Mediated DNA Mismatch Repair Gene MSH2 in Human Uterine Fibroids
Zhang CY, Dong X, Gao J, Lin W, Liu Z, Wang Z