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doi: 10.1186/s12883-023-03049-1 59 DouaudGLeeSAlfaro-AlmagroFArthoferCWangCMcCarthyPet al

Additional important points represent a source of concern, such as the significantly higher rate of hospitalization for heart failure with saxagliptin reported in the SAVOR-TIMI 53 trial [58], the fact that the research regarding dutogliptininitially considered a promising selective DPP4 inhibitor [146] was abruptly discontinued without giving any reason [63] and the finding of hyperuricemia in patients treated with teneligliptin [129]

Acknowledgements We thank all who made contributions to the manuscript

Since leptin reduces sweet taste sensitivity, diminished leptin signaling in the CNS may contribute to the reduced sweet taste sensitivity observed in individuals with obesity (127)

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