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Circulating MOTS-c levels rise approximately 1.6-fold during exercise and 1.5-fold post-exercise before returning to baseline

The following adverse reactions associated with the use of oral formulations of levocarnitine were identified in clinical trials or post-marketing reports

The anticonvulsant valproic acid (Depakene) interferes with L-carnitine biosynthesis in the liver and forms with L-carnitine a valproylcarnitine ester that is excreted in the urine

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ALA increased also the level of GSH both in in vitro and in vivo experimental models [29,30]

Most patients experience mild to moderate nausea that can be managed through dietary modifications, such as eating smaller, more frequent meals and avoiding high-fat or spicy foods that may exacerbate symptoms