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In this regard, it is interesting that IgG antibodies that show similar FcRn binding properties can have variable plasma half-lives due to differences in biophysical properties, such as pI and net charge, which affect cellular handling 83,84,85,86,87

A very-low-fat, whole-food plant-based diet addresses the actual driver of insulin resistance: intracellular fat that blocks insulin from doing its job

Pharmacokinetics (Coskun et al., Cell Metabolism 2022) Phase 1 PK data established the ~6-day half-life and once-weekly dosing rationale

This approach represents a fundamental shift from the conventional more is better mentality in medicine

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