However, native GLP-1 has a very short half-life of approximately two minutes due to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)
Patients with diabetic retinopathy, diabetic neuropathy, and both diabetes and hyperlipidemia had a significantly lower total and free carnitine level compared with the diabetic patients without complications or co-morbidities
In order to separate effects caused by inside-out signaling from those induced by outside-in signaling, we investigated the forces required to detach single cells from fibronectin-coated surfaces in an endothelium-free in vitro environment
The terminal carboxy group was protonated because is exposed to a lipid environment, generating a formal charge -1
It was more effectively activated by elevated levels of GSH in H1299 lung cancer cells than that in normal lung fibroblasts WI38 cells, releasing reactive alkoxyamines to capture AP sites, blocking APE1 repair, and leading to lung cancer cell death in vitro
Here is what I see most often in clinic: Patients skip breakfast because they are not hungry
