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The amounts of oxidized monomers accumulating during the induction period provide insight into early oxidation stages, while dimer and polymer formation indicates advanced oxidation

Step two: adding injectable therapy When metformin alone (or metformin plus other oral agents) fails to achieve blood sugar targets, the next decision is whether to add a GLP-1 agonist or insulin

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10.1038/s41467-018-03157-4 52

We see an increase in CI activity and ATP production to support increased mitochondrial activity