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The article reports gastrointestinal adverse events in 25 to 40 percent of participants in clinical trials, with severity often declining after four to eight weeks of continued use

Hypoglycemia Patients with Type 2 Diabetes In a trial of adult patients with type 2 diabetes and BMI greater than or equal to 27 kg/m2, clinically significant hypoglycemia (defined as a plasma glucose less than 54 mg/dL) was reported in 6.2% of WEGOVY-treated patients versus 2.5% of placebo-treated patients

Retatrutide: A Triple Threat in Obesity Treatment Retatrutide, a novel investigational drug developed by Eli Lilly and Company, represents a significant advancement in the field of weight loss

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doi:10.1146/annurev.nutr.24.012003.132440

Another study published in the Journal of Psychopharmacology found that B12 supplements improved mood and reduced symptoms of depression in individuals with depression