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Key Takeaways: Vitamin B12 deficiency causes hair loss primarily through telogen effluvium diffuse, whole-scalp shedding B12 supports hair health by enabling red blood cell production (oxygen delivery to follicles) and DNA synthesis in rapidly dividing follicle cells Vegetarians, vegans, and people over 50 are at highest risk of B12 deficiency in India Restoring B12 to normal levels typically resolves deficiency-related hair loss within 3-6 months B12 supplementation does NOT treat androgenetic alopecia (pattern baldness) these are different conditions Vitamin B12 is consistently among the most searched hair loss causes on Google and for good reason

A., Boucher, R

Among the screened natural products, we selected (-)-Vestitol and Salviolone, two compounds with reported therapeutic effects for diseases other than AD, for further experimental investigation

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Epigenetic mechanisms are functionally essential for regulating gene expression 1,2

To further characterize this region, we generated a COP1 dimer model using AlphaFold3 prediction and superimposed it to our experimental map 50