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The other is slower but more specific (adaptive)

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S., Hepburn, J

The severity of obesity-induced inflammation correlates with the degree of obesity

These phosphorylated tyrosines serve as docking sites for adaptor proteins including insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), and Shc, which are recruited to the activated receptor and themselves become phosphorylated, initiating multiple downstream signaling cascades

Intracellular fluid (cytosol) has up to 10 mM of GSH whereas the plasma GSH concentration is very low (micromolar range) (Forman et al., 2009)