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Vigorous shaking or agitation can shear the delicate peptide chains, especially larger ones like IGF-1 LR3

Importantly, whilst there was no significant difference between groups in diabetes duration at screening, graphs showed that seven participants in liraglutide arm had duration 5 years, but only four participants in placebo had duration 5 years

McElroy SL, Guerdjikova AI, Blom TJ, et al

292 , H3052H3056 (2007)

The two compounds engage complementary mechanisms