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However, adverse effects may limit the treatment potential, e.g., glitazones are associated with phenotypical weight gain [136] and obeticholic acid induced pruritus and elevated LDL-C [137], the latter a potential concern in patients already at risk for cardiovascular disease
It was found that the expression of GCH1 triggers the production of potent antioxidants BH4/BH2, which can block lipid peroxidation and ferroptosis, whether supplemented exogenously or produced endogenously
In addition, similar findings were seen in males treated with a lower dose of clonidine (30 mcg/kg/day) in combination with 50 mg/kg/day of methylphenidate and a decrease in femur length was observed in females treated with clonidine alone at the end of the recovery period
Ch c mt lng thuc rt nh b thy phn to thnh acid glutamic, cystein v glycin di xc tc ca nhng enzym c hiu
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