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10.3390/nu6020697 38 KooltheatN.SranujitR.LuetragoonT.YuchatM.AdulyaritthikulP.ChaisomboonC.et al (2017)

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Pairwise differences between treatments were analyzed by one-way ANOVA, and a post hoc Fishers least significant difference test was used

It is endogenously biosynthesised in the liver and kidneys from lysine and methionine through a four-step pathway proceeding via trimethyllysine and gamma-butyrobetaine, the final hydroxylation being catalysed by gamma-butyrobetaine dioxygenase