Key Differences at a Glance Dosing Wegovy pill: Daily tablet on an empty stomach Injectable GLP-1s: Weekly self-injection Weight Loss Wegovy pill: ~1317% at 64 weeks Injectable GLP-1s: ~15%+ at 68 weeks Blood Sugar Impact Wegovy pill: Strong effect on insulin resistance with modest A1c reduction Injectables: Slightly greater A1c reductions overall Side Effects Wegovy pill: Similar GI effects (nausea, diarrhea)
Just like Ozempic or Wegovy (semaglutide), retatrutide is a glucagon-like peptide-1 (GLP-1) agonist
That said, microdose does not mean no side effects. Any GLP-1-based medication can cause adverse effects, and some patients may still be sensitive even at lower doses
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If dizziness persists beyond week 3 at any dose level, pausing the next increase for 12 weeks allows your cardiovascular system to stabilize before continuing upward
However, previously, widespread shortages of injectable GLP-1s such as Ozempic and Wegovy disrupted care
