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However, many subjects have difficulty achieving the required circulating levels of 25(OH)VD even after high-dose VD supplementation, and randomized controlled clinical trials have reported limited therapeutic success post-VD supplementation

The mechanism has been demonstrated in cell culture, in animal models, and through heterologous expression experiments

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Laboratory findings indicate that both peptides promote extracellular matrix reorganization and reduce pro-inflammatory signaling, collectively fostering an environment conducive to tissue regeneration

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