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Native GLP-1 is rapidly cleaved (half-life of 1 to 2 min) by the ubiquitously expressed serine protease dipeptidyl peptidase-4 (DPP-4) and undergoes quick renal elimination [34, 4042]

Death from cardiovascular causes or a worsening heart-failure event occurred in 9.9% of the tirzepatide group versus 15.3% of the placebo group

Furthermore, in our discussion, we highlighted the immense potential of spatial omics technologies in unraveling the molecular mechanisms of OA and in the development of novel therapeutic strategies, proposing future research directions and challenges

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2.1.2 Alcohol-induced reward Although high-level consumption of alcohol over a prolonged period of time is important for the development of AUD, other fundamental aspects of this complex disorder need to be considered