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The slowed digestion also helps decrease blood sugar spikes, and the satiety effect of GLP1- agonists reduces food intake, appetite, and hunger

Lower-dose therapy did not fully match continued high-dose therapy, but it preserved a large amount of the benefit

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doi:10.1021/acs.biochem.7b00492 48

This reduction in taste reward may contribute to the weight loss effects

The disadvantage is the metabolic disruption of stopping and starting, which may reduce the efficiency of subsequent treatment courses