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The oxidative damage mediated by ROS resulting in the defect in control of apoptosis or programmed cell death and delayed clearance of apoptotic cells may prolong interaction between ROS and apoptotic cell macromolecules generating neoepitopes that subsequently broad spectrum of autoantibody formation leading to the tissue damage in SLE [6,7]

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Step-Down Criteria Step back to the previous dose if nausea or vomiting persists at grade 2 severity (interfering with daily activities) for more than three consecutive weeks at a new dose level

Different therapeutic regimens have been employed to mitigate this debilitating disease

HDACs, histone deacetylases