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Additionally, impaired GABA synthesis, due to glutamic acid decarboxylase (GAD1) dysfunction, diminishes synaptic GABA levels, further contributing to excitability [4]

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Kafi et al

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The symptoms are triggered by activities such as walking and tend to diminish or disappear when at rest

In mammals, sulforaphane can similarly upregulate stress-induced signaling pathways, including the Nuclear Factor Erythroid 2-related Factor 2 (NRF2) transcriptional pathway, which is conserved across mammalian species, but absent from plants (Gacesa et al., 2016