In vitro, GLP-1GIPLani had indistinguishable effects on incretin receptor signalling compared with its GLP-1GIP co-agonist backbone, and this was verified by equal potentiation of glucose-stimulated insulin secretion in isolated mouse islets (Fig
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reported that treatment of diabetic NOD mice with a combination of immunosuppressive therapy and Exendin-4, a GLP-1 mimetic, resulted in an increase in pancreatic insulin content and complete remission in 90% of treated mice, as compared to mice treated with the independent therapies (97)
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