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Liraglutide Attenuates Cardiac Remodeling and Improves Heart Function After Abdominal Aortic Constriction Through Blocking Angiotensin II Type 1 Receptor in Rats

One natural concern: glucagon normally raises blood sugar

29 In terms of the nervous system, GLP-1 receptor (GLP-1R) expression is enriched in central nervous system (CNS) regions, including the hypothalamus, which regulates appetite, and the brainstem, which primarily secretes brain-derived GLP-1, as well as in the peripheral vagus nerve

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Klein S., Staring M., Murphy K., Viergever M.A., Pluim J.P.W

It slows gastric emptying, meaning food sits in the stomach longer and satiety signals reach the brain sooner

Another systematic review found that people were able to maintain weight loss when they took a GLP-1 for two years or more