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Classic symptoms of an acute gout attack include: Sudden, severe joint pain , often beginning at night or early morning Most commonly affects the big toe (first metatarsophalangeal joint), though ankles, knees, wrists, and fingers can also be affected Intense inflammation with redness, warmth, and swelling around the affected joint Extreme tenderness even the weight of bedsheets may be unbearable Symptoms peak within 12-24 hours and may last several days to weeks if untreated Patients should be aware that gout attacks can be triggered during weight loss for several reasons

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Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism

In all individual domains, the AM-301 group had larger improvements than the saline spray group

J Alzheimers Dis (2018) 65:122536