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Semaglutide, a type of GLP-1R agonists with 94% sequence homology to GLP-1 and with an extended half-life of approximately 1 week, has been clinically approved to treat T2DM and is available in subcutaneous and oral dosage form (136, 137)

Do not use pens that have become too warm or have frozen

This matters because Ozempic users don't need additional appetite stimulation, and hormonal disruptions could complicate their protocol

As with any medication, adjusting to GLP-1 therapy can come with some side effects, particularly digestive issues like nausea, diarrhea, and constipation

As previously reported, AKT1 plays a key role in several cellular processes, including the regulation of mitochondrial dynamics by influencing the expression of proteins related to mitochondrial fusion and fission (Xie et al., 2022)

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