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Biochemistry Research International

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These include: Nausea the most frequently reported adverse effect, particularly during dose escalation Vomiting Diarrhoea Constipation Decreased appetite (which, whilst therapeutically intended, can occasionally be excessive) Abdominal discomfort or pain These effects are generally dose-dependent and tend to be most pronounced during the initial weeks of treatment or when the dose is increased

The prior pharmacotherapy might have an influence on the levels of the measured individual baseline enzymatic activities and, hence, the patient clustering, but presently we can only note this fact to analyze larger groups in the future

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