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Delayed gastric emptying associated with GLP1/GIP receptor agonists can increase the risk of developing appendicitis due to changes in gastrointestinal motility

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IGF-1 LR3 Clinical Evidence Context Direct human evidence on IGF-1 LR3 There are no published human clinical trials of IGF-1 LR3 itself

ATTAIN-1 (NCT05869903) The key trial for the obesity indication, ATTAIN-1 randomized 3,127 adults with obesity or overweight (without diabetes) to orforglipron 6 mg, 12 mg, or 36 mg versus placebo for 72 weeks

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