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Long-term hyperglycemia causes depressive behaviors in mice with hypoa ctive glutamatergic activity in the medial prefrontal cortex, which is not reversed by insulin treatment

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Downregulating the expression of miR-23a and increasing the expression of the mitochondrial protective gene peroxisome proliferators-activated receptor- coactivator-1 (PGC-1) can exert an anti-apoptotic effect on human hepatocytes [34]

For instance, a 36-week study with children aged 3-12 years found no serious side effects and highlighted that sulforaphane was very well tolerated