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"Hydroquinone inhibits the tyrosinase enzymes that are necessary for darkening the skin," explains Corey L

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Further mechanistic investigations determined that the elevation of intracellular GSSG levels resulted in NF-B inhibition by facilitating glutathionylated IKK- (IKK--SSG) formation, leading to enhanced TNF hepatotoxicity

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For instance, the downregulation of GPx4 has been correlated with the manifestation of radiation injury in various tissues including the intestine, hemopoietic system, lung, cardiovascular system, ovary, and skin of the murine model though enhancing the ferroptosis mode of cell death [67]

doi: 10.3748/wjg.v27.i28.4653 119 LiYLiuCZhangXHuangXLiangSXingFet al