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[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Al-Daghri N.M., Bukhari I., Yakout S.M., Sabico S., Khattak M.N.K., Aziz I., Alokail M.S

Week 7-8 (or 13-16): For persistent poor responders, consider final increase to 450-500mcg nightly, though additional benefit often minimal