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Studies have also shown that infection with various helminth species can reduce the severity of diseases, including chemically-induced colitis (Fox et al., 2000

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This matters because peptide quality, dosing accuracy, and patient selection all affect safety

( It is generally recommended that the assays to assess T-cell responses elicited by peptide impurities be performed using the same concentration as the API (formulated in saline), as this allows for direct comparison of relative immunogenicity