Using the BioGRID database 26 as a reference, we find that interactions of 158 of these targets with human pathogenic viruses have been reported before, which represents a highly significant enrichment among reported interactions between enzymes and viruses (Fishers exact test p = 9.1 10 12 , odds ratio 1.93.4) and supports their central role in viral replication across diverse viruses
Interestingly, a specific GPX1 polymorphism resulting in a proline-to-leucine transition at position 198 (Pro198Leu) is associated with a reduction in GPx1 activity and found to be more prevalent in Keshan patients
Although ferroptosis was first described in cancer cells [10] and its role in cancer biology is well established [11], its relevance has been extended to other diseases such as neurodegeneration, ischemia, and immune disorders [5]
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AFB 1 results in a significant and concentration-dependent increase in intracellular ROS production in BCMs because a main source of ROS can be mitochondrial respiratory chain uncoupling (133)
To complement the Western Blot results, the percentage of cross-reactivity (quantitative analysis) was also evaluated for all ELISA kits used
