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10,14 The light, modifier subunit provides a regulatory function, while GCLC is responsible for the catalytic activity, which conjugates sulfur-containing cysteine with glutamate, forming -glutamylcysteine
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We therefore measured G protein-dependent cAMP generation and -arrestin-1 and -2 recruitment with exendin-4, exendin-phe1, and exendin-asp3 at two time-points to avoid kinetic artefacts 38 , and calculated the pathway bias by fitting the response data to a modified form of the operational model of agonism 39 (Fig
The interplay between NRF2 and the enzyme CHAC1 is crucial in the regulation of cellular redox homeostasis and response to stress
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