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Gene delivery In vitro and in vivo studies have proven the efficacy of IGF-1 gene therapy in OA treatment [16, 60, 61]
Generally, t 1/2 values of peptide drugs range from a few minutes to an hour ( The radioisotope probe assay is a cost-effective and fast method for generating informative data for early preclinical/pharmacokinetic absorption, digestion, metabolism, and excretion studies of biotherapeutics ( Determination of metabolites was the most challenging aspect of this study
The most common operations are supravesical urinary diversion +/- cystectomy, or supratrigonal cystectomy + cystoplasty with ileum and/or cecum
Reference: Horn DB, Ryan DH, Kis SG, et al
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