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The most frequently reported issues include nausea, constipation, headache, dizziness, insomnia, and dry mouth

10.1038/s41366-020-0535-5 Int

Dorsomedial hypothalamus GLP-1R are known to be expressed in the neurons of the DMH of mice and humans, and previous studies have emphasized its role in regulating metabolic responses by exendin-4 [68,69]

In fact, I wouldnt be surprised if10 years from nowwe consider proactively microdosing GLP-1s the fourth arm of hormone therapy, right alongside estradiol, progesterone, and testosterone

Do they have promise

The two primary end points were a composite of death from cardiovascular causes or a worsening heart failure and the change from baseline to 52 weeks in the Kansas City Cardiomyopathy Questionnaire