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Preclinical evidence indicates that specific ratios of THC and CBD may produce effects that differ from those observed when each compound is administered alone

In December 2025, Eli Lilly released Phase 3 results from the TRIUMPH-4 trial that were even more striking: 28.7% average body weight loss (approximately 71 pounds) over 68 weeks

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A 2024 analysis in The Lancet Diabetes & Endocrinology found that of the total weight lost on GLP-1 receptor agonists over 36-72 weeks, 25-39% represented lost muscle mass (rather than fat loss) [4]

The list price for popular GLP-1 drugs is roughly $1,000 to $1,200 for a month's supply or $12,000-plus per year