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Uda J et al

The STAT3 pathway, when improperly regulated, amplifies inflammatory cascade reactions by upregulating key genes responsible for Th17 cell differentiation, a primary driver of tissue damage in inflammatory bowel disease

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When administered at doses of 0, 0.1, 0.25, and 0.5 ug/mL, growth hormone receptor expression was increased in a dose-dependent manner

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The only retrospective human study included 12 patients who received intra-articular BPC-157 for chronic knee pain, of whom 7 reported symptom improvement lasting more than 6 months