At physiological pH and 0.3 mM concentration, ureate, an ionized form of UA, scavenges 1 O 2 species
Indeed, assessments of functional phagocytic differences under conditions that more closely replicate the in vivo state (i.e., in media consisting of autologous PD sera) indicate increased, rather than reduced, beadphagocytic capacity, contrasting with results obtained after prolonged incubation in artificial media [111]
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In: Mahmoud, B.H
This background suggests that the optimal condition for a drug to be more efficient in carrying out its therapeutic action would be to cross a BBB with good vascular integrity and without further damage in the neuronal functional state