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FDA Registration: In the United States, reputable manufacturers should be registered with the FDA

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In general, semaglutide (Wegovy ) and tirzepatide (Zepbound ) are FDA-approved for weight loss in people with: A BMI of 30 or higher , or A BMI of 27 or higher with at least one weight-related condition, like type 2 diabetes or high blood pressure Each medication also has additional FDA-approved uses beyond weight loss: Wegovy is also approved to reduce the risk of major cardiovascular events like heart attack and stroke in adults with cardiovascular disease