Lahner E, Annibale B
In vitro , Cur restores expression of SOCS1 and SOCS3, and inhibits expression of IL-6, TNF-, and PGE2 in RAW 264.7 macrophages (Guimaraes et al., 2013), while in vivo it restores immunological balance by acting on JAK/STAT/SOCS signaling, inhibiting JAK2, STAT3, and STAT6 phosphorylation and increasing SOCS1, SOCS3, and PIAS3 expression (Zhang et al., 2016a)
Ann N Y Acad Sci 887:1830
While these are some of the most promising BPC-157 and TB-500 benefits, research suggests other potential therapeutic applications
Preclinical safety studies identify potential toxicities, dose-limiting effects, and target organs that may require monitoring
Until then, it remains a compound to watch a glimpse at the future of non-stimulant, hormone-based weight management therapies