Similarly to the ALK-5, SMAD2/3/4 gene silencing did not alter gene expression of the major effector and downstream target of TGF-, PAI-1 (Supplementary Figs
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After coronary artery ligation in mice, intraperitoneal T4 treatment upregulated cardiac ILK and Akt activity, enhanced early myocyte survival, and improved cardiac function establishing the mechanistic basis for the cardiac and broader tissue-repair claims associated with thymosin beta-4 and its 1723 fragment TB-500
J., Cordes, S