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The competitive IRAP inhibitor 23 (HA08) enhances the numbers of dendritic spines in hippocampal cell cultures and HA08 treatment resulted in an increasing number of stubby and mushroom-like spines, a morphology typically associated with mature spines, which are believed to have strengthened synaptic connectivity

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2014;8(3):e2743

As we grow older, oxidative stress increases damaging cells, accelerating wrinkles, reducing collagen production, and impairing cognitive function

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All animals were kept in well-ventilated polypropylene cages (Tarson, India) with rice husk utilized as bedding materials