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What happens if you stop GLP-1s

And Semaglutide might be it

Contraindications:: Patients with a personal or family history of medullary thyroid carcinoma (based upon animal data - see FDA Warning) History of hypersensitivity to semaglutide or any of its excipients (serious reactions including angioedema & anaphylaxis have been reported) Side Effects: GI Adverse events: nausea, vomiting, constipation, diarrhea (~5-15%) most GI side side effects occur during dose initiation or escalation and wane after a few weeks (Drucker, 2024)

4.R&D pipeline

Additionally, retatrutide lowered blood glucose and insulin levels, suggesting that retatrutide enhanced insulin sensitivity

Participants were randomized to placebo, dulaglutide 1.5 mg (active comparator), or one of four retatrutide dose groups (0.5 mg, 4 mg, 8 mg, 12 mg)