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Up to 25% of people prescribed metformin, a biguanide and first-line oral agent for type 2 diabetes, report adverse GI effects, primarily diarrhoea and nausea

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It is a physiological response that can be managed with the right strategy

This is the schedule for cobalamin injections and monitoring that the Gastrointestinal Laboratory at Texas A&M University currently recommends: Every 7 days for 6 weeks, then one dose after 30 days, and retesting 30 days after the last dose

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