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Any trauma to the skin, including UV and chemical exposure, heat, cuts, bruises, irritation, hair removal, and acne, can cause the inflammation that triggers the skins protective melanin response (hyperpigmentation)

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Interestingly, interventions that boost NAD + levels resulted in extended lifespan in worms and mice 108,109,111,247 , suggesting a therapeutic potential for raising NAD + in various pathological conditions or age-associated diseases

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