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In a resignation message shared publicly by the president, Makary defended his record, citing what he described as dozens of major reforms, including sharply shortened drug review timelines, new guidance for psychedelic therapies, a plausible mechanism pathway for rare disease drugs, and changes to estrogen labelling

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Methods Study subjects This study was approved by the Institutional Review Board of the Baylor College of Medicine Biomedical Research and Assurance Information Network (BRAIN) under protocol number H-31612

All data were log transformed prior to analysis and were converted back to the linear scale for presentation

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