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Danuglipron and orforglipron are nonpeptide oral GLP-1R agonists in development that have shown encouraging safety and efficacy in glycemic control among patients with T2DM [179]

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Between now and those two dates, expect the agency to continue updating the 503A bulks reference document as nominations come in, get withdrawn, get clarified, and shift between categories

A plausible laboratory mechanism is a reason to investigate further, not a substitute for well-designed human evidence

But both guys have never had any issues off the field, Beane said