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Overall, we identified 280 pre-clinical and mechanistic studies (Fig

Refer to our How to Handle Common Side Effects with Diet section above for more information

At 48 weeks on the 12 mg dose, 100% of participants achieved at least 5% weight reduction, 93% achieved at least 10%, and 83% achieved at least 15%

But obesity-related health costs are already high and rising

In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: 15.0% for 5 mg, 19.5% for 10 mg, 20.9% for 15 mg, compared to 3.1% for placebo [18]

Dispatched from the UK