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By competitively binding to p53, FOXO4-DRI displaces endogenous FOXO4, causing p53 nuclear exclusion and translocation to mitochondria where it triggers the intrinsic apoptotic pathway through caspase-3/7 activation

1-10 mg/kg in animal studies Combined formulations: Ratios vary widely across research suppliers (5-50mg GHK-Cu, 5-10mg BPC-157, 5-10mg TB-500) Important: These are experimental doses used in animal studies and cannot be extrapolated to other species due to significant differences in metabolism, receptor density, pharmacokinetics, and peptide degradation rates

Intended Research Use IGF-1 LR3 is intended solely for laboratory and scientific research

doi: 10.1016/0361-9230(87)90069-4

Age-related weight gain

ISBN 978-1-4612-8799-5