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Alongside impairments in carbohydrate metabolism, evidence of reduced carnitine levels suggest a dysfunction in mitochondrial -oxidation, leading to accumulation of long-chain fatty acids and elevated markers of lipid elongation and desaturation (Pastural et al., 2009)

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Management of associated conditions is essential: Diabetes control : Pioglitazone and GLP-1 receptor agonists (such as liraglutide or semaglutide) show hepatic benefits in clinical trials, but their use for NASH is off-label in the UK and should be initiated and monitored by specialists after careful riskbenefit discussion

moreover, similar GLP-1RA effect sizes suggest a lack of sufficient power rather than a lack of effect

USA 100 , 94169421 (2003)

Jim Green: Compositionally, Jupiter and Saturn are pretty similar